Abstract
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
MeSH terms
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Cell Line, Tumor
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Chromatography, Liquid
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Humans
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Indicators and Reagents
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Ligands
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Nucleotides / chemical synthesis*
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Nucleotides / chemistry
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Nucleotides / pharmacology*
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Purinergic P2 Receptor Agonists*
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Receptors, Purinergic P2Y2
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Recombinant Proteins
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Spectrophotometry, Ultraviolet
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Uridine Triphosphate / chemistry*
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Uridine Triphosphate / pharmacology
Substances
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Indicators and Reagents
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Ligands
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Nucleotides
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P2RY2 protein, human
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Purinergic P2 Receptor Agonists
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Receptors, Purinergic P2Y2
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Recombinant Proteins
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Uridine Triphosphate